The CMC-like behaviour of bile salts as probed by photoexcited Rose Bengal
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Effects of rose bengal on bile secretion in the rabbit: inhibition of a bile salt-independent fraction.
The authors have studied the influence of rose bengal, and, by comparison, of uranin, on choleresis in the rabbit. Uranin induced an increase in bile flow and a decrease in bile salt concentration in bile. These results are consistent with an osmotic mechanism, as proposed by Sperber (1959). By contrast, rose bengal induced a marked decrease in bile flow and an increase in bile salt concentrati...
متن کاملPotent bile salt and organic anion inhibition of methotrexate uptake and accumulation in the freshly isolated rat hepatocyte.
Influx of [3H]methotrexate into freshly isolated hepatocytes is mediated by highand low-affinity processes, both of which are inhibited by the bile salts, cholate, taurocholate, and de oxycholate, and the organic anions, bromosulfophthalein and rose bengal. At 100 @Mconcentrations, these compounds inhibit 1 @LM [3H]methotrexate influx by 70 to 90%. Dixon plots established a similar K (-@†̃20 @...
متن کاملThe influence of bile salt structure on self-association in aqueous solutions.
The relationship between chemical structure and the concentration at which self-association occurs in water or in 0.15 M Na+ ion was examined for more than 50 bile salts and bile salt analogues varying in substituents on the steroid nucleus or in the structure of the side chain. Nuclear substituents varied in type (alpha- or beta-hydroxy, or oxo group) and number (1, 2, or 3); side chain struct...
متن کاملPotent Bile Salt and OrganicAnionInhibitionof Methotrexate Uptake and Accumulation in the Freshly Isolated Rat Hepatocyt&
Influx of [3H]methotrexate into freshly isolated hepatocytes is mediated by highand low-affinity processes, both of which are inhibited by the bile salts, cholate, taurocholate, and de oxycholate, and the organic anions, bromosulfophthalein and rose bengal. At 100 @Mconcentrations, these compounds inhibit 1 @LM [3H]methotrexate influx by 70 to 90%. Dixon plots established a similar K (-@†̃20 @...
متن کاملTransport of conjugated bilirubin and other organic anions in bile: relation to biliary lipid structures.
Using gel-permeation chromatography, we studied associative relationships between conjugated bilirubin and various biliary lipid particle species, including lecithin/cholesterol vesicles, mixed-lipid micelles, and simple bile salt micelles. Five other organic anions were comparably studied: phenol red, Evans blue, sulfobromophthalein, rose bengal, and indocyanine green. For compounds of interme...
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تاریخ انتشار 2009